The natural world provides a host of materials and inspiration for the field of nanomedicine. For instance, photo-based hyperthermia and reactive oxygen species (ROS) have been reported to induce immunogenic cell death for enhanced tumor immunogenicity 7, 8. Cancer nanomedicine, in combination with immunotherapy, offers great potential to amplify antitumor immune responses and sensitize tumors to immunotherapy in a safe and effective manner 6. However, clinical data suggest that only a small fraction (10–30%) of patients respond to the ICB 5. For instance, immune checkpoint blockade (ICB) can be applied to durably eliminate tumors by inhibiting intrinsic down-regulators of immunity, thus boosting the therapeutic efficacy 4. Collectively, the present study demonstrates biological precipitation synthetic strategy of targeted nanoparticles holds great potential for the preparation of microbial membrane-based nanoplatforms to boost antitumor immunity.Ĭancer immunotherapy has been revolutionizing oncology and demonstrating varying degrees of success in certain solid cancers 1, 2, 3. In two tumor-bearing mouse models using female mice, MiBaMc triggered phototherapy synergizes with anti-PDL1 blocking antibody for enhanced tumor inhibition. The released tumor antigens subsequently promote the maturation of dendritic cells in tumor-draining lymph nodes, eliciting T cell-mediated immune response. We find that MiBaMc specifically targets mitochondria and induces amplified photo-damages and immunogenic cell death of tumor cells under light irradiation. We present a mitochondria-targeting nanoplatform, MiBaMc, which consists of Prussian blue decorated bacteria membrane fragments having further modifications with chlorin e6 and triphenylphosphine. Here, electrochemically active Shewanella oneidensis MR-1 can be applied to produce FDA-approved Prussian blue nanoparticles on a large-scale. The marriage of nanotechnology and immunotherapy offers a great opportunity to amplify antitumor immune response in a safe and effective manner. This image is compatible with Squarespace, Wix, WordPress, Webflow, and all the popular website publishing suites that allow for you to post pics.Cancer immunotherapy is revolutionizing oncology. Yes, you may download and use Eco-Earth pic on your website. These images scale without loss of quality, and will even look great on large-format posters and in high DPI. Yes, this picture is suitable for printing, and will look great on posters, flyers, and handouts. The SVG can then be imported into your office software whether that be Microsoft Office, Apple Pages, or LibreOffice. You can download this graphic as a high quality SVG file that scales to any size without becoming blurry. Yes, this clip art is 100% compatible with Microsoft Office including Microsoft Word and PowerPoint. Can I use this Eco-Earth clip art in Microsoft Office? Because there is no fee attached to using the image, it's perfect for use in advertising and marketing materials, classrooms, and as part of your product. You may use, distribute, or even sell this image without paying any royalties nor giving any credit. Yes, this clipart is completely free to use, including for commercial purposes. Frequently Asked Questions Is the Eco-Earth clip art free to use?
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